The National Public Health Agency (NPHA) is Sierra Leone's premier institution for public health protection, preparedness, and response. Established in 2023, the NPHA plays a pivotal role in preventing, detecting, and responding to public health threats through a responsive, science-driven, and coordinated public health system.

Operating under the Ministry of Health, the NPHA leads national efforts in evidence-based policy development, surveillance, emergency response, and systems strengthening — positioning Sierra Leone to meet its public health goals and global health obligations, including the International Health Regulations (IHR) and the Sustainable Development Goals (SDGs).